Research/Clinical Trials

The research team at the Columbia Hypertrophic Cardiomyopathy (HCM) Center focuses on revealing the underlying mechanisms that lead to the development of HCM and to discover novel biomarkers in the blood that can identify patients with HCM who are more likely to experience adverse cardiovascular events (e.g., arrhythmias, stroke, congestive heart failure, and sudden cardiac death). Additionally, we utilize large “real-world” databases to compare the effectiveness and safety of the available treatments for HCM. Our group is actively recruiting patients to participate in several trials. If interested, please contact us at 212-305-8013.

Publications

• Shimada YJ, Tsugawa Y, Brown DFM, Hasegawa K. Association between Bariatric Surgery and Rate of Emergency Department Visits and Hospitalizations for Heart Failure Exacerbation among Obese Patients with Heart Failure. J Am Coll Cardiol. 2016;67(8):895-903. PMID: 26916477.
• Shimada YJ, Passeri JJ, Baggish AL, O'Callaghan C, Lowry PA, Yannekis G, Abbara S, Ghoshhajra BB, Rothman RD, Ho CY, Januzzi JL, Seidman CE, Fifer MA. Effects of losartan on left ventricular hypertrophy and fibrosis in patients with nonobstructive hypertrophic cardiomyopathy. JACC: Heart Failure. 2013;1(6):480-7. PMID: 24621999.
• McCullough SA, Fifer MA, Mohajer P, Lowry PA, Reen CO, Baggish AL, Vlahakes GJ, Shimada YJ. Clinical Correlates and Prognostic Impact of Elevated Right Atrial Pressure in Patients with Hypertrophic Cardiomyopathy. Circulation Journal. 2018;82(5):1405-1411. PMID: 29526913
• Shimada YJ, Cannon CP. PCSK9 (Proprotein convertase subtilisin/kexin type 9) inhibitors: past, present, and the future. Eur Heart J. 2015;36(36):2415-24. Review. PMID: 25971287.
• Shimada YJ, Weiner S, Takayama H. How AMAZING is A MAZE Procedure in the HOCM Population? Journal of Thoracic and Cardiovascular Surgery. 2017 (in press). Editorial.
• Shimada YJ, Farrell LA, Gerszten RE, Fifer MA. Diagnostic Value of Metabolite Profiling in Patients with Hypertrophic Cardiomyopathy [abstract]. J Am Coll Cardiol. 2017;69 (11 Suppl.):837
• Shimada YJ, et al. Comparative effectiveness of alcohol septal ablation versus septal myectomy on acute care use for cardiovascular disease in patients with hypertrophic cardiomyopathy [abstract]. European Heart Journal. 2018;39 (suppl_1):3547.
• Shimada YJ, et al. Proteomics Profiling Reveals Molecular Pathways Enriched in Hypertrophic Cardiomyopathy [abstract]. Circulation. 2018.
• Shimada YJ, Hasegawa K, et al. Bariatric Surgery is Associated with Lower Risk of Acute Care Use for Cardiovascular Disease in Obese Adults. Cardiovascular Research. 2018 (in press).
• Shimada YJ, Tsugawa Y, Iso H, Brown DFM, Hasegawa K. Association between Bariatric Surgery and Risk of Hospitalizations for Stable Angina Pectoris in Obese Adults. Heart. 2017;103(13):1009-1014. PMID: 28209590.
• Shimada YJ, Tsugawa Y, Camargo CA, Brown DFM, Hasegawa K. Effect of Bariatric Surgery on Emergency Department Visits and Hospitalizations for Atrial Fibrillation. Am J Cardiol. 2017;120(6):947-952. PMID: 28734462.
• Shimada YJ, Tsugawa Y, Iso H, Brown DFM, Hasegawa K. Association of Bariatric Surgery with Risk of Acute Care Use for Hypertension-Related Disease in Obese Adults: Population-Based Self-Controlled Case Series Study. BMC Med. 2017;15(1):161. PMID: 28830535.
• Shimada YJ, Cannon CP, Liu Y, Wilson C, Kupfer S, Menon V, Cushman WC, Mehta CR, Bakris GL, Zannad F, White WB. Ischemic Cardiac Outcomes and Hospitalizations According to Prior Macrovascular Disease Status in Patients with Type 2 Diabetes and Recent Acute Coronary Syndrome from the EXAMINE trial. American Heart Journal. 2016;175:18-27.
• Shimada YJ, Bansilal S, Wiviott SD, Becker RC, Harrington RA, Himmelmann A, Neely B, Husted S, James SK, Katus HA, Lopes RD, Steg PG, Storey RF, Wallentin L, Cannon CP; PLATO Investigators. Impact of Glycoprotein IIb/IIIa Inhibitors on the Efficacy and Safety of Ticagrelor Compared to Clopidogrel in Patients with Acute Coronary Syndromes - Analysis from the PLATO (Platelet Inhibition and Patient Outcomes) Trial. American Heart Journal. 2016;177:1-8. PMID: 27297843
• Shimada YJ, Yamashita T, Koretsune Y, Kimura T, Abe K, Sasaki S, Mercuri M, Ruff CT, Giugliano RP. Effects of Regional Differences in Asia on Efficacy and Safety of Edoxaban Compared to Warfarin: Insights from the ENGAGE AF-TIMI 48 Trial. Circulation Journal. 2015;79(12):2560-7. PMID: 26460886.
• Shimada YJ, Shiota M, Siegel RJ, Shiota T. Accuracy of right ventricular volumes and function determined by three-dimensional echocardiography in comparison with magnetic resonance imaging: a meta-analysis study. J Am Soc Echocardiogr. 2010;23(9):943-953. PMID: 20797527.
• Shimada YJ, Shiota T. A meta-analysis and investigation for the source of bias of left ventricular volumes and function by three-dimensional echocardiography in comparison with magnetic resonance imaging. Am J Cardiol. 2011;107(1):126-138. PMID: 21146700.
• Shimada YJ, Ishikawa K, Kawase Y, Ladage D, Tilemann L, Shiota T, Hajjar RJ. Comparison of left ventricular stroke volume assessment by two- and three-dimensional echocardiography in a swine model of acute myocardial infarction validated by thermodilution method. Echocardiography. 2012;29(9):1091-5. PMID: 22672366.
• Shimada YJ, Shiota T. Meta-analysis of accuracy of left ventricular mass measurement by three-dimensional echocardiography. Am J Cardiol. 2012;110(3):445-52. PMID: 22541420.
• Shimada YJ, Shiota T. Underestimation of left atrial volume by 3-dimensional echocardiography validated by magnetic resonance imaging: a meta-analysis and investigation of the source of bias. Echocardiography. 2012;29(4):385-90. PMID: 22150607.
• Shimada YJ, Nakra NC, Fox TJ, Kanei Y. Relation of race to activated clotting time after weight adjusted bolus of heparin during percutaneous coronary intervention. Am J Cardiol. 2010;105(5):629-632. PMID: 20185008.
• Shimada YJ, Nakra NC, Fox JT, Kanei Y. Meta-analysis of prospective randomized controlled trials comparing intracoronary versus intravenous abciximab in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Am J Cardiol. 2012;109(5):624-8. PMID: 22152971.
• Funakoshi T, Shimada YJ. Risk of hypothyroidism in patients with cancer treated with sunitinib: a systematic review and meta-analysis. Acta Oncol. 2013;52(4):691-702. PMID: 23282114.
• Shimada YJ, Po JR, Kanei Y, Schweitzer P. Prognostic impact of terminal T wave inversions on presentation in patients with ST-elevation myocardial infarction undergoing urgent percutaneous coronary intervention. J Electrocardiol. 2013;46(1):2-7. PMID: 23312357.
• Kato S, Chernyavsky S, Tokita JE, Shimada YJ, Homel P, Rosen H, Winchester JF. Relationship between proteinuria and venous thromboembolism. J Thromb Thrombolysis. 2010;30(3):281-5. PMID: 20157844.
• Kato S, Shimada YJ (first co-author), Friedmann P, Kashan G, Husk G, Bergmann SR. Identification of residual risk factors for the development of venous thromboembolism in medical inpatients receiving subcutaneous heparin therapy for prophylaxis. Coron Artery Dis. 2012;23(4):294-7. PMID: 22421548.
• Miyata-Fukuoka Y, Izumo M, Shimada Y, Kuwahara E, Gurudevan SV, Tolstrup K, Siegel RJ, Shiota T. Left atrial size and function are related to pulmonary hypertension in coronary artery disease. Echocardiography. 2012;29(5):535-40. PMID: 22324451.
• Hyodo E, Arai K, Koczo A, Shimada YJ, Fujimoto K, Di Tullio MR, Homma S, Gillam LD, Hahn RT. Alteration in subendocardial and subepicardial myocardial strain in patients with aortic valve stenosis: an early marker of left ventricular dysfunction? J Am Soc Echocardiogr. 2012;25(2):153-9. PMID: 22129776.
• Ishikawa K, Fish KM, Tilemann L, Rapti K, Aguero J, Santos-Gallego CG, Lee A, Karakikes I, Xie C, Akar FG, Shimada YJ, Gwathmey JK, Asokan A, McPhee S, Samulski J, Samulski RJ, Sigg DC, Weber T, Kranias EG, Hajjar RJ. Cardiac I-1c overexpression with reengineered AAV improves cardiac function in swine ischemic heart failure. Mol Ther. 2014;22(12):2038-45. PubMed PMID: 25023328.
• Yamashita T, Koretsune Y, Yang Y, Chen S, Chung N, Shimada YJ, Kimura T, Miyazaki K, Abe K, Mercuri M, Ruff CT, Giugliano RP. Edoxaban vs. Warfarin in East Asian Patients With Atrial Fibrillation. An ENGAGE AF-TIMI 48 Subanalysis. Circulation Journal. 2016;80(4):860-9. PMID: 26888149.
• Hasegawa K, Gibo K, Tsugawa Y, Shimada YJ, Camargo CA Jr. Age-related differences in the rate, timing, and diagnosis of 30-day readmissions in hospitalized adults with asthma exacerbation. Chest. 2016;149(4):1021-9. PMID: 26836926.
• Watanabe Y, Iwamura A, Shimada YJ, Wakai K, Tamakoshi A, Iso H; JACC Study Group. Transforming Growth Factor-β1 as a Predictor for the Development of Hepatocellular Carcinoma: A Nested Case-Controlled Study. EBioMedicine. 2016;12:68-71. pii: S2352-3964(16)30408-X. PMID: 27614396.
• Makker P, Shimada YJ, Misra D, Kanei Y. Clinical Effect of Rebound Hyperthermia After Cooling Postcardiac Arrest: A Retrospective Cohort Study. Ther Hypothermia Temp Manag. 2016 Oct 26. PMID: 27782794.
• Hirayama A, Goto T, Shimada YJ, Faridi MK, Camargo CA Jr, Hasegawa K. Association of Obesity With Severity of Heart Failure Exacerbation: A Population-Based Study. J Am Heart Assoc. 2018 Mar 15;7(6).
• Goto T, Shimada YJ, Faridi MK, Camargo CA Jr, Hasegawa K. Incidence of acute cardiovascular event after acute exacerbation of COPD. J Gen Intern Med. 2018 (in press).
• Hirayama A, Shimada YJ, Hasegawa K, et al. Acute exacerbation of chronic obstructive pulmonary disease and subsequent risk of emergency department visits and hospitalizations for atrial fibrillation. Circulation: Arrhythmia and Electrophysiology. 2018 (in press).