Publications
Selected Publications
* Indicates senior author, underlining indicates mentees.
Leroy C. Joseph, Dimitra Kokkinaki, Mesele-Christina Valenti, Grace J. Kim, Emanuele Barca, Dhanendra Tomar, Nicholas E. Hoffman, Prakash Subramanyam, Henry M. Colecraft, Michio Hirano, Adam J. Ratner, Muniswamy Madesh, Konstantinos Drosatos*, John P. Morrow*. Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function. JCI Insight, 2017, 10.1172/jci.insight.94248
Shuang Zhang, Xin-Yi Yeap, Matthew DeBerge, Nivedita K. Naresh, Kevin Wang, Zhengxin Jiang, Jane E. Wilcox, Steven M. White, John P.Morrow, Paul W. Burridge, Daniel Procissi, Evan A. Scott, William Frazier, Edward B. Thorp. Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair. JACC Basic to Translational Science, 2017, 2(4): DOI: 10.1016/j.jacbts.2017.03.013
Caroline Le Dour, Coline Macquart, Fusako Sera, Shunichi Homma, Nicolas Vignier, Gisele Bonne,John P. Morrow, Antoine Muchir, Howard J. Worman. Decreased WNT/β-catenin signaling contributes to the pathogenesis of dilated cardiomyopathy caused by mutations in the lamin A/C gene. Human Molecular Genetics, 2017, 26(2): 333-343.
Leroy C. Joseph, Prakash Subramanyam, Christopher Radlicz, Chad M. Trent, Vivek Iyer, Henry M. Colecraft, John P. Morrow*. Mitochondrial oxidative stress during cardiac lipid overload causes intracellular calcium leak and arrhythmia. Heart Rhythm, 2016, 13(8):1699-706.
Leroy C. Joseph, Emanuele Barca, Prakash Subramanyam, Michael Komrowski, Utpal Pajvani, Henry M. Colecraft, Michio Hirano, John P. Morrow*. Inhibition of NAPDH oxidase 2 (NOX2) prevents oxidative stress and mitochondrial abnormalities caused by saturated fat in cardiomyocytes. PLOS ONE, 2016, DOI: 10.1371/journal.pone.0145750
Elaine Wan, Jeffrey Abrams, Richard L. Weinberg, Alex N. Katchman, Joseph Bayne, Sergey I. Zakharov, Lin Yang, John P. Morrow, Hasan Garan, and Steven O. Marx.Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice. Journal of Clinical Investigation,2016, doi:10.1172
Haiyan Huang, Leroy C. Joseph, Michael Gurin, Edward Thorp, John P. Morrow*. Extracellular signal-regulated kinase activation during cardiac hypertrophy reduces sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) transcription. Journal of Molecular and Cellular Cardiology, 2014, 75: 58–63
Lin Yang, Alexander N. Katchman, Tahmina Samad, John P. Morrow, Richard Weinberg and Steven O. Marx. Beta-Adrenergic Regulation of the L-type Ca2+ Channel Does Not Require Phosphorylation of a1C Ser1700. Circulation Research, 2013, 113:871-880.
Elaine Wan, Xin Yi Yeap, Shirley Dehn, Rachael Terry, Margaret Novak, Shuang Zhang, Shinichi Iwata, Xiaoqiang Han, Shunichi Homma, Konstantinos Drosatos, Jon Lomasney, David M. Engman, Stephen D. Miller, Douglas E. Vaughan, John P. Morrow, Raj Kishore, and Edward B. Thorp. Enhanced Efferocytosis of Apoptotic Cardiomyocytes Through MER Tyrosine Kinase Links Acute Inflammation Resolution to Cardiac Repair After Infarction. Circulation Research, 2013, 113:1004-1012.
Haiyan Huang, Vaibhav Amin, Michael Gurin, Elaine Wan, Edward Thorp, Shunichi Homma, John P. Morrow*. Diet-induced obesity causes long QT and reduces transcription of voltage-gated potassium channels. Journal of Molecular and Cellular Cardiology, 2013, 59: 151–158
Arthur R Garan, Kerry Morrison, Laurie Letarte, Jesus Vazquez, Drew Dano, Paolo Colombo, Melana Yuzefpolskaya, Rosie Te-Frey, Hiroo Takayama, Yoshifumi Naka, John Morrow, Hasan Garan, Ulrich P Jorde, Nir Uriel. Ventricular Arrhythmias in Patients Following Continuous Flow Left Ventricular Assist Device Implantation. JACC, 2013, 61(25): 2542-50
Jason C. Choi, Antoine Muchir, Wei Wu, Shinichi Iwata, Shunichi Homma, John Morrow, Howard J. Worman. Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation. Science Translational Medicine, 2012, 4: 144ra102
John P. Morrow, Alex Katchman, Ni-Huiping Son, Chad M. Trent, Raffay Khan, Takayuki Shiomi, Haiyan Huang, Vaibhav Amin, Joshua M. Lader, Carolina Vasquez, Gregory E. Morley, Jeanine D'Armiento, Shunichi Homma, Ira J. Goldberg, Steven O. Marx. Mice with cardiac overexpression of PPARgamma have impaired repolarization and spontaneous fatal ventricular arrhythmias. Circulation, 2011, 124:2812-2821
John P. Morrow, Sergey I. Zakharov, Guoxia Liu, Lin Yang, Andrea Sok, Steven O. Marx. Defining the BK channel domains required for Beta-1 subunit modulation. Proceedings of the National Academy of Science, 2006, vol 103: 5096-5101