Clinical Trials
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Principal Investigator:
Tamim M. Nazif, MDThis prospective, multicenter trial is looking at the investigative device called the ACURATE Transcatheter Aortic Valve System for TAVR to see if it is safe and effective in treating patients with severe symptomatic native aortic stenosis. The ACURATE Transcatheter Aortic Valve System for TAVR is designed for iliofemoral access and delivery of a self-expanding implant that restores competency in a sclerotic aortic valve. To implant the device, a surgical incision is made in the femoral vein (incision in the upper leg between the knee and the hip). A catheter is advanced into the heart access... -
Principal Investigator:
Susheel Kumar Kodali, MDThe objective of the study is to evaluate the safety and efficacy of the JenaValve Pericardial TAVR system when treating patients with aortic regurgitation. Aortic Regurgitation is a condition that develops when the heart's aortic valve does close tightly, therefore the blood leaks back into the heart chamber. The JenaValve Pericardial TAVR system will be used to treat this condition and restore proper flow blood. Treatment of aortic regurgitation with the JenaValve provides a controlled valve release and deployment during the entire implantation procedure under beating heart conditions,... -
Principal Investigator:
Susheel Kumar Kodali, MDThe goal of this early feasibility study is to gain initial insight into the basic safety and performance of transluminal (through the blood vessels) implantation of the PASCAL Systems implant (composed of man-made materials). We are trying to evaluate the safety and performance of the PASCAL System with Optimal Medical Therapy (OMT) (also known as standard of care) compared to OMT alone in participants with symptomatic severe tricuspid regurgitation who may not be ideal candidates for tricuspid valve surgery (tricuspid valve repair that is performed via open-heart surgery) and may be... -
Principal Investigator:
Susheel Kumar Kodali, MDThe Edwards Cardioband Tricuspid Valve Reconstruction FIT valve repair system is a prospective, single arm, multi-center study to evaluate the safety and performance of the Cardioband Tricuspid System. The Edwards Cardioband Tricuspid Valve Reconstruction System is intended for patients with tricuspid regurgitation deemed to be potential candidates for transcatheter tricuspid valve reconstruction with the Edwards Cardioband Tricuspid Valve Reconstruction System by the local Heart Team. -
Principal Investigator:
Muredach Patrick Reilly, MDAs an academic medical center, we are always working to improve patient and population health. One way that research is supported here is through the Columbia University Biobank (CUB). A biobank is a collection of biological samples and health data that is collected during a patient's medical care. The goal of a biobank is to provide materials for researchers to use in their scientific studies of health conditions such as cancer, heart disease, and diabetes. People who participate in a biobank help researchers find treatments and cures, and they also help their community benefit from improved... -
Principal Investigator:
Vivian Gar-Yan Ng, MDThe purpose of this study is to find out, in patients with CAD who had successful TAVR with a balloon expandable heart valve, whether restoring blood flow to all blocked or narrowed arteries via PCI using coronary stents (metal scaffold) is better than treating the coronary artery disease with medications only following TAVR. The study will also compare measurements of hemodynamics (blood flow and blood pressure) that are taken during on-table procedures (TAVR and PCI) with those taken by echocardiography (heart ultrasound). These measurements are all taken as a part of standard practice for... -
Principal Investigator:
Andrew J. Einstein, MD, PhD*COVID Cohort* We are seeking patients that have had a pre-COVID heart CT scan (Coronary Computed Tomography Angiography) that was performed at Columbia University Irving Medical Center/NewYork-Presbyterian Hospital before March of 2020. For this study, half of patients will be required to have had COVID-19 symptoms (e.g., fever, cough, shortness of breath) and would have tested positive for COVID-19 (by an FDA-approved test). The other half will not have had a prior diagnosis of COVID-19. If you enroll in the study, you will be given a CT, asked to provide a blood sample as well as answer... -
Principal Investigator:
Andrew J. Einstein, MD, PhD*Non-COVID* We are seeking patients that have had a pre-COVID heart CT scan (Coronary Computed Tomography Angiography) that was performed at Columbia University Irving Medical Center/NewYork-Presbyterian Hospital before March of 2020. For this study, half of patients will be required to have had COVID-19 symptoms (e.g., fever, cough, shortness of breath) and would have tested positive for COVID-19 (by an FDA-approved test). The other half will not have had a prior diagnosis of COVID-19. If you enroll in the study, you will be given a CT, asked to provide a blood sample as well as answer the... -
Principal Investigator:
Edward Felix Lin, MDThe purpose of this study is to collect data about congestive heart failure over several months from patients at home and to assess the ability of a newly developed wireless device to accurately measure changes in the heart and lungs due to CHF. A secondary aim is to determine if the device may predict hospitalizations before they occur. -
Principal Investigator:
Marwah Abdalla, MDThe Center for Behavioral Cardiovascular Health (CBCH) is conducting a research study to examine the impacts on blood pressure when it is measured with and without someone in the room with you. Two-part screening to determine eligibility for this study involves a) answering questionnaires and b) measuring your arm circumference. Participation in the research study involves 1-2 study visits, wearing a wrist activity monitoring device for 8 days, wearing a blood pressure measurement device for 24 hours and taking your blood pressure 4 times a day for 7 days, receiving daily text messages and...