John Pearce Morrow, MD
Overview
As a physician-scientist I devote 75% of my time to laboratory research. My work as a clinical cardiologist informs my translational research program. My ultimate goal is to develop novel therapeutics to prevent and treat the cardiac complications of metabolic diseases.The goal of my research is to determine the molecular mechanisms that cause arrhythmias and cardiomyopathy during metabolic stress. My laboratory investigates disease models of chronic metabolic stress (e.g. obesity) and acute metabolic stress (e.g. sepsis), using molecular biology, cellular physiology, and in vivo techniques.
Areas of Expertise / Conditions Treated
- Cardiac Electrophysiology
Academic Appointments
- Assistant Professor of Medicine at CUMC
Administrative Titles
- Co-Director of Cardiology Grand Rounds
- Assistant Professor, Department of Medicine, Division of Cardiology
Hospital Affiliations
- NewYork-Presbyterian / Columbia University Irving Medical Center
Languages
- Spanish
Gender
- Male
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Location(s)
Credentials & Experience
Education & Training
- Columbia University College of Physicians and Surgeons
- Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
- Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center
Committees, Societies, Councils
2015 - present Member of the Society of General Physiologists
2014 - present Member of the New York Obesity Nutrition Research Center
An NIH funded center that provides infrastructure for studies related to metabolism, nutrition and obesity.
2012 - present Fellow of the Heart Rhythm Society
2007 - present Member of the Heart Rhythm Society
2004 - present Member of the American Heart Association (AHA)
Board Certifications
- Cardiovascular Disease
- Clinical Cardiac Electrophysiology
- Internal Medicine
Honors & Awards
2011 Teacher of the Year, Cardiology Training Program, CUMC
2009 Katz Prize in Cardiovascular Research, CUMC
2005 Hamilton Southworth Research Award for Fellows, CUMC
Research
The goal of my research is to determine the molecular mechanisms that cause arrhythmias and cardiomyopathy during metabolic stress. My laboratory investigates disease models of chronic metabolic stress (e.g. obesity), using molecular biology, cellular physiology, and in vivo techniques. Little is known about the contribution of metabolic abnormalities to the pathophysiology of heart failure, arrhythmias, and hypertrophy. I have extensive experience with standard molecular biology techniques, cell culture, immunohistochemistry, cardiomyocyte isolation, patch clamp, and small animal survival surgery.
I have long-term collaborations with other researchers at my own institution and at other universities. I am a member of the NY Obesity Nutrition Research Center (NYONR) an NIH funded center that provides infrastructure for studies related to metabolism, nutrition and obesity. I am also dedicated to educating and training the next generation of cardiovascular researchers, both students and post-docs. Several students have completed master’s theses in my lab. I have also served on the thesis committee of PhD students.
As a physician-scientist I devote 75% of my time to laboratory research. My work as a clinical cardiologist informs my translational research program. My ultimate goal is to develop novel therapeutics to prevent and treat the cardiac complications of metabolic diseases.
Research Interests
- cardiac metabolism
- Ion channel regulation
- Obesity/metabolic syndrome
- Translational research in cardiac electrophysiology
Selected Publications
1. Leroy C. Joseph, Prakash Subramanyam, Christopher Radlicz, Chad M. Trent, Vivek Iyer, Henry M. Colecraft, John P. Morrow*. Mitochondrial oxidative stress during cardiac lipid overload causes intracellular calcium leak and arrhythmia. Heart Rhythm, 2016, in press.
2. Leroy C. Joseph, Emanuele Barca, Prakash Subramanyam, Michael Komrowski, Utpal Pajvani, Henry M. Colecraft, Michio Hirano, John P. Morrow*. Inhibition of NAPDH oxidase 2 (NOX2) prevents oxidative stress and mitochondrial abnormalities caused by saturated fat in cardiomyocytes. PLOS ONE, 2016, DOI: 10.1371/journal.pone.0145750
3. Elaine Wan, Jeffrey Abrams, Richard L. Weinberg, Alex N. Katchman, Joseph Bayne, Sergey I. Zakharov, Lin Yang, John P. Morrow, Hasan Garan, and Steven O. Marx. Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice. Journal of Clinical Investigation, 2015, doi:10.1172
4. Shuang Zhang, Xin-Yi Yeap, Lubov Grigoryeva, Shirley Dehn, Matthew DeBerge, Michael Tye, Emily Rostlund, Dorien Schrijvers, Zheng Jenny Zhang, Ronen Sumagin, Warren G. Tourtellotte, Daneil Lee, Jon Lomasney, John Morrow, Edward B. Thorp. Cardiomyocytes induce macrophage receptor shedding to suppress phagocytosis. Journal of Molecular and Cellular Cardiology, 2015, 87: 171-179
5. Ji-Yeon Shin, Caroline Le Dour, Fusako Sera, Shinichi Iwata, Shunichi Homma, Leroy C. Joseph, John P. Morrow, William T. Dauer, Howard J. Worman. Depletion of lamina-associated polypeptide 1 from cardiomyocytes causes cardiac dysfunction in mice. Nucleus, 2014, 5(3):260-459
6. Haiyan Huang, Leroy C. Joseph, Michael Gurin, Edward Thorp, John P. Morrow*. Extracellular signal-regulated kinase activation during cardiac hypertrophy reduces sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) transcription. Journal of Molecular and Cellular Cardiology, 2014, 75: 58-63
7. Lin Yang, Alexander N. Katchman, Tahmina Samad, John P. Morrow, Richard Weinberg and Steven O. Marx. Beta-Adrenergic Regulation of the L-type Ca2+ Channel Does Not Require Phosphorylation of a1C Ser1700. Circulation Research, 2013, 113:871-880.
8. Elaine Wan, Xin Yi Yeap, Shirley Dehn, Rachael Terry, Margaret Novak, Shuang Zhang, Shinichi Iwata, Xiaoqiang Han, Shunichi Homma, Konstantinos Drosatos, Jon Lomasney, David M. Engman, Stephen D. Miller, Douglas E. Vaughan, John P. Morrow, Raj Kishore, and Edward B. Thorp. Enhanced Efferocytosis of Apoptotic Cardiomyocytes Through MER Tyrosine Kinase Links Acute Inflammation Resolution to Cardiac Repair After Infarction. Circulation Research, 2013, 113:1004-1012.
9. Haiyan Huang, Vaibhav Amin, Michael Gurin, Elaine Wan, Edward Thorp, Shunichi Homma, John P. Morrow*. Diet-induced obesity causes long QT and reduces transcription of voltage-gated potassium channels. Journal of Molecular and Cellular Cardiology, 2013, 59: 151-158
10. Arthur R Garan, Kerry Morrison, Laurie Letarte, Jesus Vazquez, Drew Dano, Paolo Colombo, Melana Yuzefpolskaya, Rosie Te-Frey, Hiroo Takayama, Yoshifumi Naka, John Morrow, Hasan Garan, Ulrich P Jorde, Nir Uriel. Ventricular Arrhythmias in Patients Following Continuous Flow Left Ventricular Assist Device Implantation. JACC, 2013, 61(25): 2542-50
11. Jason C. Choi, Antoine Muchir, Wei Wu, Shinichi Iwata, Shunichi Homma, John Morrow, Howard J. Worman. Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation. Science Translational Medicine, 2012, 4: 144ra102
12. Antoine Muchir, Wei Wu, Jason C. Choi, Shinichi Iwata, John Morrow, Shunichi Homma and Howard J. Worman. Abnormal p38a mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A/C gene mutation. Human Molecular Genetics, 2012, 1-9
13. Lin Yang, Alexander Katchman, John P. Morrow, Darshan Doshi, and Steven O. Marx. Cardiac L-Type Calcium Channel Associates with Gamma Subunits. FASEB Journal, 2011, 25(3):928-36
14. John P. Morrow, Alex Katchman, Ni-Huiping Son, Chad M. Trent, Raffay Khan, Takayuki Shiomi, Haiyan Huang, Vaibhav Amin, Joshua M. Lader, Carolina Vasquez, Gregory E. Morley, Jeanine D'Armiento, Shunichi Homma, Ira J. Goldberg, Steven O. Marx. Mice with cardiac overexpression of PPARgamma have impaired repolarization and spontaneous fatal ventricular arrhythmias. Circulation, 2011, 124:2812-2821
15. Lin Yang, Darshan Doshi, John Morrow, Alexander Katchman, Xiang Chen, Steven Marx. PKC isoforms differentially phosphorylate Cav1.2 alpha1c. Biochemistry, 2009, vol 48(28): 6674-6683
16. John P. Morrow, Sergey I. Zakharov, Guoxia Liu, Lin Yang, Andrea Sok, Steven O. Marx. Defining the BK channel domains required for Beta-1 subunit modulation. Proceedings of the National Academy of Science, 2006, vol 103: 5096-5101
17. Lin Yang, Guoxia Liu, Sergey I. Zakharov, John P. Morrow, Vitali O. Rybin, Susan F. Steinberg, and Steven O. Marx. Ser1928 Is a Common Site for Cav1.2 Phosphorylation by Protein Kinase C Isoforms. Journal of Biological Chemistry, 2005, vol 280: 207 - 214
18. Sergey I. Zakharov, John P. Morrow, Guoxia Liu, Lin Yang, and Steven O. Marx. Activation of the BK (SLO1) Potassium Channel by Mallotoxin. Journal of Biological Chemistry, 2005, vol 280: 30882 - 3088
19. Mintoo Patel, John Morrow, Frederick R. Maxfield, Dudley K. Strickland, Steven Greenberg, and Ira Tabas. The cytoplasmic domain of the low density lipoprotein (LDL) receptor-related protein, but not that of the LDL receptor, triggers phagocytosis. Journal of Biological Chemistry, 2003, vol 278: 44799-44807
20. Haifeng Xue, David O'Neill, John Morrow, and Arthur Bank. A novel mouse gene, Hem T, encoding an hematopoietic cell-specific transcript. Gene, 1999, vol 231: 49-58
For a complete list of publications, please visit PubMed.gov
Global Health Activities
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