Our Projects

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Hypertension

  • Effects of a Multi-faceted Intervention on Blood Pressure Actions in the Primary Care Environment

    • Ian Kronish, MD, MPH

    What is the Embrace Study?

    Approximately 1 in 3 patients has elevated blood pressure (BP) when measured in the doctor’s office, but normal BP when measured out of the office setting, a phenomenon known as white coat hypertension. Misdiagnosing such patients with hypertension can lead to unnecessary treatment with blood pressure (BP) medications, wasteful healthcare utilization, and adverse psychological consequences due to labeling effects. In 2015, the United Services Preventive Services Task Force (USPSTF) updated their hypertension screening guidelines to recommend that patients with elevated office BP undergo out-of-office BP testing with 24-hour Ambulatory BP Monitoring (ABPM) or Home BP Monitoring (HBPM) to rule-out white-coat hypertension prior to a new diagnosis of hypertension.

    Despite the USPSTF recommendation, ABPM and HBPM are infrequently utilized in the US. Accordingly, the investigators conducted focus groups with primary care providers, patients, and other key stakeholders to identify the major barriers to implementation of the new hypertension screening guidelines. The investigators then applied the Behavior Change Wheel, a trans-theoretical intervention development framework, to categorize barriers and select theory-informed intervention components that would address these barriers.

    The investigators arrived at a theory-informed implementation strategy comprised of the following 7 components:

    • educational activities for providers
    • training registered nurses to teach patients how to conduct HBPM
    • disseminating information on how to order ABPM and HBPM to clinicians
    • creating a computerized electronic health record-embedded clinical decision support tool that prompts recall of the guideline and facilitates ABPM and HBPM test ordering
    • creating and disseminating patient information materials on ABPM and HBPM
    • providing periodic feedback about clinic-level success with adhering to the guideline
    • developing an easily accessible, culturally-adapted and locally tailored ABPM service

    The investigators conducted a 2-year cluster randomized trial that tested whether this multifaceted implementation strategy increases the uptake of the USPSTF hypertension recommendations in the Ambulatory Care network (ACN) of New York-Presbyterian Hospital (NYP), a network of primary care clinics serving 120,000 patients from underserved communities in New York City. Click here to view study results: https://clinicaltrials.gov/ct2/show/NCT03480217.

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  • Implementing Remote Patient Monitoring to Improve Hypertension Control in a Primary Care Network: The MonitorBP Cluster Randomized Trial

    • PI Ian Kronish, MD, MPH

    Hypertension guidelines now strongly recommend that hypertensive patients monitor their blood pressure (BP) at home (i.e., home blood pressure monitoring; HBPM) for better control, especially when conducted with clinical support (i.e., Supported HBPM). Despite proven benefits from randomized clinical trials (RCTs), less than 20% of hypertensive patients regularly monitor their blood pressure at home, creating a gap in translating recommendations into practice.

    Accordingly, in partnership with health system leaders at New York-Presbyterian Hospital, Columbia University Irving Medical Center, and Weill Cornell Medicine, we leveraged a system-wide investment in telemedicine to develop a Supported HBPM program. The program consists of two options for obtaining electronic health record (EHR)-integrated home BP data: 1) a low resource intensity option designed for patients that can obtain valid home BP devices and are comfortable using the patient portal and 2) a high resource intensity option that includes navigator support with using loaned home BP devices that wirelessly transmit data into the EHR. Both programs can be ordered by clinicians in the EHR and provide clinicians with a weekly summary of home BP readings with average BP calculated. The study team concurrently followed a theory-driven process (the Behavior Change Wheel) to develop an implementation strategy aimed at increasing uptake of the Supported HBPM program by clinicians and patients.

    To assess its impact, we are now conducting a cluster randomized trial across 15 primary care practices. Practices are assigned to early implementation of the Supported HBPM program or a wait-list control. The primary outcome is the change in clinic mean systolic blood pressure over 12 months. We will also evaluate the implementation strategy's success in increasing program uptake among patients and clinicians, using the RE-AIM framework to assess clinical and implementation effectiveness. Additionally, cost-effectiveness will be explored through simulation modeling.

Depression

  • A theoretical approach to improving patient engagement and shared decision making for minorities in collaborative depression care (Transform DepCare)

    • PI: Nathalie Moise, MD, MS, FAHA

    What is DepCare?

    Sustainable models for integrating mental health in primary care have been limited by suboptimal mental health screening, lack of primary care provider time for quality discussions, limited resources/access and patient stigma and treatment misconceptions. In response, a multidisciplinary team of providers, patients, and mental health workers in the ACN created DepCare, a personalized, culturally tailored, web-based application aimed at improving depression screening, education and management in primary care settings. DepCare uses a crossover design to test a multi-level optimization strategy centered around a tool for improving screening, patient activation, and automated shared decision-making, as well as provider education/feedback, to improve the delivery of care for depression by internists in primary care clinics across NYPH. The intervention combines cutting edge implementation science methods, based on transtheoretical behavioral change frameworks and user-centered design principles, to design an intervention tailored to address patient-, provider- and clinic-level barriers to maximize depression treatment optimization (AHRQ Moise PI).

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  • An Information tecHnology approach to implEmenting depression treAtment in caRdiac patienTs: [iHeart Trial]

    • PI: Nathalie Moise, MD, MS, FAHA

    What is iHeartDepCare?

    Despite extensive research on the relationship between depression and heart disease mortality, heart disease patients remained sub-optimally screened and treated for depression. iHeart tests a theory-informed multi-level implementation strategy centered around patient activation with the goal of improving the uptake of depression treatment and reducing maladaptive behaviors in coronary heart disease patients (NHLBI PI Moise). 

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Cardiac Rehab

  • Implementing Telehealth-enhanced Hybrid Cardiac Rehabilitation (THCR) among Acute Coronary Syndrome Survivors: A Pilot Randomized Controlled Trial

    • PI: Andrea Duran, PhD

    Cardiac Rehabilitation (CR)—which involves exercise training and health behavior modification in clinic- and/or home-based settings—is a Class I, Level A secondary prevention program that significantly reduces reinfarction and mortality rates in acute coronary syndrome (ACS) survivors. Yet, fewer than 30% of eligible cardiac patients participate in CR programs in the United States. Given the unprecedented impact of COVID-19 on our healthcare system, CR participation has declined even further.

    One promising avenue for increasing CR participation in the post-COVID-19 era is a telehealth-enhanced hybrid CR (THCR) model, combining telehealth, clinic- and home-based CR. The degree and optimal design (e.g., frequency/duration of home- vs. clinic-based sessions) by which THCR improves clinical outcomes among ACS survivors remains unknown. Moreover, few if any studies have examined how best to address patient, provider, and organizational barriers to implementing a THCR model in ACS patients. This project launches an interdisciplinary program of research across the fields of implementation science, behavioral medicine, telehealth, and exercise physiology to address these gaps.

    The goals of this pilot study are to (1) test the feasibility of conducting a single center, two-arm, 1:1 parallel group randomized clinical trial of THCR compared with traditional CR in ACS survivors, and (2) investigate multi-level barriers and facilitators to implementing THCR among this population. These results will then be used to develop theory-informed, multilevel implementation strategies in a future hybrid type II effectiveness-implementation trial.

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De-implementation

  • De-implementation of Mammography Overuse in Older Racially and Ethnically Diverse Women

    • MPI(s): Parisa Tehranifar, DrPH; Rachel Shelton, ScD, MPH; Nathalie Moise, MD, MD, FAHA

    De-implementation is recognized as a critical but understudied area within implementation science (IS). Research is needed to determine the optimal methods and approaches for identifying, selecting, and tailoring de-implementation strategies. De-implementation of routine cancer screening in older adults, such as mammography screening for breast cancer, offers excellent opportunities for both advancing the science of de-implementation and improving care delivery and health outcomes in older adults

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