Yuichi Shimada, MD, MPH
Overview
Dr. Shimada received MD degree from The University of Tokyo in 2007. He was selected as one of the 2 exchange medical students who were allowed to experience a three-month sub-internship at Johns Hopkins Hospital, where he decided to pursue his career as a physician-scientist in the United States. After graduation, he served as a house staff at the University of Tokyo Hospital (2007-2008).
Dr. Shimada completed Internal Medicine residency at Beth Israel Medical Center (2008-2011) and was selected as Chief Medical Resident (2011-2012). He moved on to cardiology fellowship at Brigham & Women’s Hospital, Harvard Medical School (2012-2015). He also honed his clinical research skills at TIMI Study Group and Harvard Clinical Research Institute during the fellowship. He spent the last year of his cardiology fellowship as the first “hypertrophic cardiomyopathy fellow” at Massachusetts General Hospital, Harvard Medical School (2014-2015). Concurrently with his residency and fellowship, he enrolled in the Master of Public Health Program at Johns Hopkins (2011-2014) and was inducted into the Delta Omega Alpha Public Health Honor Society at Hopkins.
After graduating from his fellowship in 2015, Dr. Shimada served as an attending cardiologist of the Hypertrophic Cardiomyopathy Program at Massachusetts General Hospital (2015-2017). He joined the faculty of the Division of Cardiology at Columbia University Irving Medical Center in 2017.
Dr. Shimada has served as an ad-hoc reviewer/judge for research grant funding systems of American Heart Association (5 times), University of Muenster (Germany), and Swiss National Science Foundation (twice). He is an editorial board member of 3 peer-reviewed scientific journals. He has performed peer-review as an ad-hoc reviewer for >40 scientific journals, and the list includes top journals such as Circulation, European Heart Journal, Journal of the American College of Cardiology, JAMA Cardiology, and Annals of Internal Medicine. He has also received multiple awards and prizes for his research and gave >100 invited lectures nationally and internationally (e.g., Portugal, Korea, and Japan). Dr. Shimada has been a site investigator and site principal investigator of several multi-center, international, randomized controlled trials on hypertrophic cardiomyopathy and heart failure. Additionally, Dr. Shimada serves as a Board Member and Chair of Scholarship Committee at Japanese Medical Society of America.
Academic Appointments
- Associate Professor of Medicine
Administrative Titles
- Director of Research, Hypertrophic Cardiomyopathy Center
Hospital Affiliations
- NewYork-Presbyterian / Columbia University Irving Medical Center
Languages
- Japanese
Gender
- Male
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Location(s)
Credentials & Experience
Education & Training
- University of Tokyo Faculty of Medicine (Japan)
- Johns Hopkins Bloomberg School of Public Health
- Internship: University of Tokyo Hospital
- Residency: Beth Israel Medical Center
- Fellowship: Massachusetts General Hospital, Harvard Medical School
Committees, Societies, Councils
Member, Delta Omega Alpha Public Health Honor Society at Johns Hopkins Bloomberg School of Public Health
Member, American Heart Association
Member, American College of Cardiology
Board Member, Japanese Medical Society of America
Member, The Japanese Circulation Society
Member, The Japanese Society of Internal Medicine
Board Certifications
- Internal Medicine
- Cardiovascular Disease
Honors & Awards
2023 R01 Award (R01-HL168382; sole PI), National Institute of Health
2021 R01 Award (R01-HL157216; sole PI), National Institute of Health
2021 The Lewis Katz Cardiovascular Research Prize, Columbia University Irving Medical Center
2021 Medical Research Award, The Feldstein Medical Foundation
2021 Research Grant, Korea Institute of Oriental Medicine
2021 Career Development Award (COVID Relief Supplement), American Heart Association
2018 Precision Medicine Pilot Award, Columbia University Irving Medical Center Irving Institute for Clinical & Translational Research
2018 Career Development Award, American Heart Association
2018 Research Grant, Korea Institute of Oriental Medicine
2017 Mentored Clinical & Population Research Award, American Heart Association
2017 Tosteson-Fund for Medical Discovery Award, Massachusetts General Hospital
2015 National Mentored Clinical & Population Research Award, American Heart Association
2014 Cardiovascular Board Review Scholarship Award, American College of Cardiology’s Cardiovascular Board Review Course
2014 Finalist, Capstone Award, Johns Hopkins Bloomberg School of Public Health
2014 Delta Omega Alpha Public Health Honor Society at Johns Hopkins
2013 Fellows-in-Training Travel Award, ACC.13 Council on Cardiovascular Care of Older Adults
2012 The Honjo International Scholarship Foundation Award
2012 First Prize, Case Report Category, Alumni Association Annual Paper Competition, Beth Israel Medical Center Abstract and Poster Competition
2012 First Prize, Beth Israel Medical Center Research Fair Abstract and Poster Competition
2011 The Japanese Medical Society of America/ Mitsui-USA Scholarship Award
2011 Finalist, American College of Physicians National Meeting Abstract and Poster Competition
2010 Third Prize, New York Chapter American College of Physicians Abstract and Poster Competition
2010 First Prize, New York Chapter American College of Physicians Abstract and Poster Competition
2009 The Japanese Medical Society of America/ Honjo Scholarship Award
Research
Selected Publications
Lumish HS, Liang LW, Hasegawa K, Maurer MS, Fifer MA, Reilly MP, Shimada YJ. Prediction of worsening heart failure in patients with hypertrophic cardiomyopathy using plasma proteomics profiling. Heart. 2023;109(24):1837-1843. PMID: 37451849.
Liang LW, Hasegawa K, Maurer MS, Fifer MA, Reilly MP, Shimada YJ. Comprehensive Transcriptomics Profiling of MicroRNA Reveals Plasma Circulating Biomarkers of Hypertrophic Cardiomyopathy and Dysregulated Signaling Pathways. Circulation: Heart Failure. In press. Mentioned by the NHLBI/NIH in their official SNS blog (twitter.com/nih_nhlbi/status/1671172327856283648).
Miyashita S, Akita K, Zhao Y, Hasegawa K, Maurer MS, Weiner SD, Reilly MP, Takayama H, Shimada YJ. Bariatric surgery is associated with lower risk of acute cardiovascular event in patients with obesity and hypertrophic cardiomyopathy. ESC Heart Failure. 2023;10(4):2438-2446. PMID: 37259234.
Lee C, Liang LW, Hasegawa K, Maurer MS, Tower-Rader A, Fifer MA, Reilly M, Shimada YJ. Proteomics profiling reveals signaling pathways associated with major adverse cardiovascular events in patients with hypertrophic cardiomyopathy. J Card Fail. 2023:S1071-9164(23)00270-1. PMID: 37562580.
Yokoyama Y, Shimoda T, Shimada YJ, Shimamura J, Akita K, Yasuda R, Takayama H, Kuno T. Alcohol septal ablation versus surgical septal myectomy of obstructive hypertrophic cardiomyopathy: systematic review and meta-analysis. Eur J Cardiothorac Surg. 2023;63(3):ezad043. PMID: 36782361.
Lander BS, Zhao Y, Hasegawa K, Maurer MS, Tower-Rader A, Fifer MA, Reilly MP, Shimada YJ. Comprehensive proteomics profiling identifies patients with late gadolinium enhancement on cardiac magnetic resonance imaging in the hypertrophic cardiomyopathy population. Front Cardiovasc Med. 2022;9:839409. PMID: 35783832.
Liang LW, Raita Y, Hasegawa K, Fifer MA, Maurer MS, Reilly MP, Shimada YJ. Proteomics profiling reveals a distinct high-risk molecular subtype of hypertrophic cardiomyopathy. Heart. 2022:heartjnl-2021-320729. PMID: 35351822.
Yamabe T, Ginns J, Vedula V, Leb JS, Shimada YJ, Weiner SD, Takayama H. Left ventricular remodeling following septal myectomy in hypertrophic obstructive cardiomyopathy. JTCVS Open. 2022;11:105-115. PMID: 36172435.
Liang LW, Kalia I, Latif F, Waase MP, Shimada YJ, Sayer G, Reilly MP, Uriel N. The use of telemedicine in cardiogenetics clinical practice during the COVID-19 pandemic. Mol Genet Genomic Med. 2022;10(6):e1946. PMID: 35388985.
Morita SX, Hasegawa K, Raita Y, Reilly MP, Fifer MA, Maurer MS, Shimada YJ. Effects of septal reduction therapy on acute cardiovascular events and all-cause mortality in patients with obstructive hypertrophic cardiomyopathy: propensity score-matched study. Int Heart J. 2021;62(5):1035-1041. PMID: 34544977.
Shimada YJ, Raita Y, Liang LW, Maurer MS, Hasegawa K, Fifer MA, Reilly MP. Prediction of major adverse cardiovascular events in patients with hypertrophic cardiomyopathy using proteomics profiling. Circulation: Genomics and Precision Medicine. 2022:e003546. PMID: 36252118. Press release from NewYork-Presbyterian/ Columbia University Irving Medical Center (https://www.nyp.org/advances-cadiology/hypertrophic-cardiomyopathy-addressing-the-compelling-need-for-warning-signals)
Shimada YJ, Raita Y, Liang LW, Maurer MS, Hasegawa K, Fifer MA, Reilly MP. Comprehensive proteomics profiling reveals circulating biomarkers of hypertrophic cardiomyopathy. Circulation: Heart Failure. 2021;14(7):e007849. PMID: 34192899.
Liang LW, Fifer MA, Hasegawa K, Maurer MS, Reilly MP, Shimada YJ. Prediction of genotype positivity in patients with hypertrophic cardiomyopathy using machine learning. Circulation: Genomics and Precision Medicine 2021;14(3):e003259. PMID: 33890823.
Morita SX, Kusunose K, Haga A, Sata M, Hasegawa K, Raita Y, Reilly MP, Fifer MA, Maurer MS, Shimada YJ. Deep learning analysis of echocardiographic images to predict positive genotype in patients with hypertrophic cardiomyopathy. Front Cardiovasc Med. 2021;8:669860. PMID: 34513940.
Kochav SM, Raita Y, Fifer MA, Takayama H, Ginns J, Maurer MS, Reilly MP, Hasegawa K, Shimada YJ. Machine learning-based prediction of cardiovascular death in patients with hypertrophic cardiomyopathy. Int J Cardiol. 2020:S0167-5273(20)34077-8. PMID: 33181159.
Shimada YJ, Batra J, Kochav SM, Patel P, Jung J, Maurer MS, Hasegawa K, Reilly MP, Fifer MA. Difference in metabolomic response to exercise between patients with and without hypertrophic cardiomyopathy. J Cardiovasc Transl Res. 2021;14(2):246-255. PMID: 32594362.
Miyashita S, Kuno T, Takagi H, Sugiyama T, Ando T, Valentin N, Shimada YJ, Kodaira M, Numasawa Y, Kanei Y, Bangalore S. Risk of amputation associated with sodium-glucose co-transporter 2 inhibitors: A meta-analysis of five randomized controlled trials. Diabetes Res Clin Pract. 2020;163:108136. PMID: 32272190.
Kuno T, Takagi H, Ando T, Sugiyama T, Miyashita S, Valentin N, Shimada YJ, Kodaira M, Numasawa Y, Briasoulis A, Burger A, Bangalore S. Oral anticoagulation for patients with atrial fibrillation on long-term hemodialysis. J Am Coll Cardiol. 2020;75(3):273-285. PMID: 31976865.
Kuno T, Takagi H, Sugiyama T, Ando T, Miyashita S, Valentin N, Shimada YJ, Kodaira M, Numasawa Y, Kanei Y, Hayashida K, Bangalore S. Antithrombotic strategies after transcatheter aortic valve implantation: Insights from a network meta-analysis. Catheter Cardiovasc Interv. 2020;96(2):E177-E186. PMID: 31609071.
Shimada YJ, Goto T, Takayama H, Brown DFM, Homma S, Maurer MS, Reilly MP, Hasegawa K. Comparison of effectiveness of alcohol septal ablation versus ventricular septal myectomy on acute care use for cardiovascular disease in patients with hypertrophic cardiomyopathy. Am J Cardiol. 2019;124(8):1272-1278. PMID: 31447010.
Shimada YJ, Hasegawa K, Kochav SM, Mohajer P, Jung J, Maurer MS, Reilly MP, Fifer MA. Application of proteomics profiling for biomarker discovery in hypertrophic cardiomyopathy. J Cardiovasc Transl Res. 2019;12(6):569-579. PMID: 31278493.
Raita Y, Camargo CA, Faridi MK, Brown DFM, Shimada YJ, Hasegawa K. Risk of acute myocardial infarction and ischemic stroke in patients with asthma exacerbation: A population-based, self-controlled case series study. J Allergy Clin Immunol Pract. 2020:188-194.e8. PMID: 31323338.
Takayama H, Yu SN, Sorabella R, Leb J, Pulerwitz TC, Cooper C, Argenio M, Shimada YJ, Weiner S, Ginns JN. Virtual septal myectomy for preoperative planning in hypertrophic cardiomyopathy. J Thorac Cardiovasc Surg. 2019;158(2):455-463. PMID: 30578058.
Yu SN, Nakanishi K, Ginns JN, Salna MP, Shimada YJ, Polanco A, Chiang Y, Weiner SD, Takayama H. Importance of surgical expertise in septal myectomy for obstructive hypertrophic cardiomyopathy. Gen Thorac Cardiovasc Surg. 2020;68(10):1094-1100. PMID: 32103394.
Shimada YJ, Hoeger CW, Latif F, Takayama H, Ginns J, Maurer MS. Myocardial contraction fraction predicts cardiovascular events in patients with hypertrophic cardiomyopathy and normal ejection fraction. Journal of Cardiac Failure. 2019;25(6):450-456. PMID: 30928539.
Shimada YJ, Goto T, Tsugawa Y, Yu EW, Yoshida K, Homma S, Brown DFM, Hasegawa K. Comparative effectiveness of gastric bypass versus gastric banding on acute care use for cardiovascular disease in obese adults. Nutrition, Metabolism, and Cardiovascular Diseases. 2019;29(5):518-526. PMID: 30935764.
Shimada YJ, Gibo K, Tsugawa Y, Goto T, Yu EW, Iso H, Brown DFM, Hasegawa K. Bariatric surgery is associated with lower risk of acute care use for cardiovascular disease in obese adults. Cardiovascular Research. 2019;115(4):800-806. PMID: 30357327.
Hirayama A, Goto T, Shimada YJ, Faridi MK, Camargo CA Jr, Hasegawa K. Acute exacerbation of chronic obstructive pulmonary disease and subsequent risk of emergency department visits and hospitalizations for atrial fibrillation. Circulation: Arrhythmia and Electrophysiology. 2018;11(9):e006322. PMID: 30354294.
Goto T, Shimada YJ, Faridi MK, Camargo CA Jr, Hasegawa K. Incidence of acute cardiovascular event after acute exacerbation of COPD. J Gen Intern Med. 2018;33(9):1461-1468. PMID: 29948806.
Hirayama A, Goto T, Shimada YJ, Faridi MK, Camargo CA Jr, Hasegawa K. Association of obesity with severity of heart failure exacerbation: a population-based study. J Am Heart Assoc. 2018;7(6). PMID: 29545263.
McCullough SA, Fifer MA, Mohajer P, Lowry PA, Reen CO, Baggish AL, Vlahakes GJ, Shimada YJ. Clinical correlates and prognostic impact of elevated right atrial pressure in patients with hypertrophic cardiomyopathy. Circulation Journal. 2018;82(5):1405-1411. PMID: 29526913.
Shimada YJ, Tsugawa Y, Iso H, Brown DFM, Hasegawa K. Association of bariatric surgery with risk of acute care use for hypertension-related disease in obese adults: population-based self-controlled case series study. BMC Med. 2017;15(1):161. PMID: 28830535.
Shimada YJ, Tsugawa Y, Camargo CA, Brown DFM, Hasegawa K. Effect of bariatric surgery on emergency department visits and hospitalizations for atrial fibrillation. Am J Cardiol. 2017;120(6):947-952. PMID: 28734462.
Shimada YJ, Tsugawa Y, Iso H, Brown DFM, Hasegawa K. Association between bariatric surgery and risk of hospitalizations for stable angina pectoris in obese adults. Heart. 2017;103(13):1009-1014. PMID: 28209590.
Makker P, Shimada YJ, Misra D, Kanei Y. clinical effect of rebound hyperthermia after cooling postcardiac arrest: a retrospective cohort study. Ther Hypothermia Temp Manag. 2017;7(3):137-140. PMID: 27782794.
Watanabe Y, Iwamura A, Shimada YJ, Wakai K, Tamakoshi A, Iso H; JACC Study Group. Transforming growth factor-β1 as a predictor for the development of hepatocellular carcinoma: a nested case-controlled study. EBioMedicine. 2016;12:68-71. pii: S2352-3964(16)30408-X. PMID: 27614396.
Shimada YJ, Bansilal S, Wiviott SD, Becker RC, Harrington RA, Himmelmann A, Neely B, Husted S, James SK, Katus HA, Lopes RD, Steg PG, Storey RF, Wallentin L, Cannon CP; PLATO Investigators. Impact of glycoprotein IIb/IIIa inhibitors on the efficacy and safety of ticagrelor compared to clopidogrel in patients with acute coronary syndromes - analysis from the PLATO (Platelet Inhibition and Patient Outcomes) trial. American Heart Journal. 2016;177:1-8. PMID: 27297843.
Hasegawa K, Gibo K, Tsugawa Y, Shimada YJ, Camargo CA Jr. Age-related differences in the rate, timing, and diagnosis of 30-day readmissions in hospitalized adults with asthma exacerbation. Chest. 2016;149(4):1021-1029. PMID: 26836926.
Yamashita T, Koretsune Y, Yang Y, Chen S, Chung N, Shimada YJ, Kimura T, Miyazaki K, Abe K, Mercuri M, Ruff CT, Giugliano RP. Edoxaban vs. warfarin in east asian patients with atrial fibrillation. An ENGAGE AF-TIMI 48 subanalysis. Circulation Journal. 2016;80(4):860-869. PMID: 26888149.
Shimada YJ, Cannon CP, Liu Y, Wilson C, Kupfer S, Menon V, Cushman WC, Mehta CR, Bakris GL, Zannad F, White WB. Ischemic cardiac outcomes and hospitalizations according to prior macrovascular disease status in patients with type 2 diabetes and recent acute coronary syndrome from the EXAMINE trial. American Heart Journal. 2016;175:18-27. PMID: 27179720.
Shimada YJ, Tsugawa Y, Brown DFM, Hasegawa K. Association between bariatric surgery and rate of emergency department visits and hospitalizations for heart failure exacerbation among obese patients with heart failure. J Am Coll Cardiol. 2016;67(8):895-903. PMID: 26916477. Press release from Massachusetts General Hospital.
Shimada YJ, Yamashita T, Koretsune Y, Kimura T, Abe K, Sasaki S, Mercuri M, Ruff CT, Giugliano RP. Effects of regional differences in Asia on efficacy and safety of edoxaban compared to warfarin: insights from the ENGAGE AF-TIMI 48 trial. Circulation Journal. 2015;79(12):2560-2567. PMID: 26460886.
Ishikawa K, Fish KM, Tilemann L, Rapti K, Aguero J, Santos-Gallego CG, Lee A, Karakikes I, Xie C, Akar FG, Shimada YJ, Gwathmey JK, Asokan A, McPhee S, Samulski J, Samulski RJ, Sigg DC, Weber T, Kranias EG, Hajjar RJ. Cardiac I-1c overexpression with reengineered AAV improves cardiac function in swine ischemic heart failure. Mol Ther. 2014;22(12):2038-2045. PMID: 25023328.
Shimada YJ, Passeri JJ, Baggish AL, O'Callaghan C, Lowry PA, Yannekis G, Abbara S, Ghoshhajra BB, Rothman RD, Ho CY, Januzzi JL, Seidman CE, Fifer MA. Effects of losartan on left ventricular hypertrophy and fibrosis in patients with nonobstructive hypertrophic cardiomyopathy. JACC: Heart Failure. 2013;1(6):480-487. PMID: 24621999.
Funakoshi T, Shimada YJ. Risk of hypothyroidism in patients with cancer treated with sunitinib: a systematic review and meta-analysis. Acta Oncol. 2013;52(4):691-702. PMID: 23282114.
Shimada YJ, Po JR, Kanei Y, Schweitzer P. Prognostic impact of terminal T wave inversions on presentation in patients with ST-elevation myocardial infarction undergoing urgent percutaneous coronary intervention. J Electrocardiol. 2013;46(1):2-7. PMID: 23312357.
Hyodo E, Arai K, Koczo A, Shimada YJ, Fujimoto K, Di Tullio MR, Homma S, Gillam LD, Hahn RT. Alteration in subendocardial and subepicardial myocardial strain in patients with aortic valve stenosis: an early marker of left ventricular dysfunction? J Am Soc Echocardiogr. 2012;25(2):153-159. PMID: 22129776.
Shimada YJ, Shiota T. Underestimation of left atrial volume by 3-dimensional echocardiography validated by magnetic resonance imaging: a meta-analysis and investigation of the source of bias. Echocardiography. 2012;29(4):385-390. PMID: 22150607.
Shimada YJ, Nakra NC, Fox JT, Kanei Y. Meta-analysis of prospective randomized controlled trials comparing intracoronary versus intravenous abciximab in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Am J Cardiol. 2012;109(5):624-628. PMID: 22152971.
Miyata-Fukuoka Y, Izumo M, Shimada Y, Kuwahara E, Gurudevan SV, Tolstrup K, Siegel RJ, Shiota T. Left atrial size and function are related to pulmonary hypertension in coronary artery disease. Echocardiography. 2012;29(5):535-540. PMID: 22324451.
Kato S, Shimada YJ (first co-author), Friedmann P, Kashan G, Husk G, Bergmann SR. Identification of residual risk factors for the development of venous thromboembolism in medical inpatients receiving subcutaneous heparin therapy for prophylaxis. Coron Artery Dis. 2012;23(4):294-297. PMID: 22421548.
Shimada YJ, Shiota T. Meta-analysis of accuracy of left ventricular mass measurement by three-dimensional echocardiography. Am J Cardiol. 2012;110(3):445-452. PMID: 22541420.
Shimada YJ, Ishikawa K, Kawase Y, Ladage D, Tilemann L, Shiota T, Hajjar RJ. Comparison of left ventricular stroke volume assessment by two- and three-dimensional echocardiography in a swine model of acute myocardial infarction validated by thermodilution method. Echocardiography. 2012;29(9):1091-1095. PMID: 22672366.
Shimada YJ, Shiota T. A meta-analysis and investigation for the source of bias of left ventricular volumes and function by three-dimensional echocardiography in comparison with magnetic resonance imaging. Am J Cardiol. 2011;107(1):126-138. PMID: 21146700.
Kato S, Chernyavsky S, Tokita JE, Shimada YJ, Homel P, Rosen H, Winchester JF. Relationship between proteinuria and venous thromboembolism. J Thromb Thrombolysis. 2010;30(3):281-285. PMID: 20157844.
Shimada YJ, Nakra NC, Fox TJ, Kanei Y. Relation of race to activated clotting time after weight adjusted bolus of heparin during percutaneous coronary intervention. Am J Cardiol. 2010;105(5):629-632. PMID: 20185008.
Shimada YJ, Shiota M, Siegel RJ, Shiota T. Accuracy of right ventricular volumes and function determined by three-dimensional echocardiography in comparison with magnetic resonance imaging: a meta-analysis study. J Am Soc Echocardiogr. 2010;23(9):943-953. PMID: 20797527.
For a complete list of publications, please visit PubMed.gov